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1

Analysis of in vivo kinetics of glycolysis in aerobic Saccharomyces cerevisiae by application of glucose and ethanol pulses

Diana Visser, Gertan A. van Zuylen, Jan C. van Dam, Michael R. Eman, Angela Pröll, Cor Ras, Liang Wu, Walter M. van Gulik, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2004

Language:

english

File:

PDF, 690 KB

english, 2004

2

Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach

Cristian Picioreanu, Mark C. M. van Loosdrecht, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

1998

Language:

english

File:

PDF, 2.54 MB

english, 1998

3

Two-dimensional model of biofilm detachment caused by internal stress from liquid flow

Cristian Picioreanu, Mark C. M. van Loosdrecht, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 821 KB

english, 2001

4

Microbial Reduction and in situ Product Crystallization Coupled with Biocatalyst Cultivation during the Synthesis of 6R-Dihydrooxoisophorone

Evelyn M. Buque-Taboada, Adrie J. J. Straathof, Joseph J. Heijnen, Luuk A. M. van der Wielen

Journal:

Advanced Synthesis & Catalysis

Year:

2005

Language:

english

File:

PDF, 380 KB

english, 2005

5

ChemInform Abstract: Exploration of Lipase-Catalyzed Direct Amidation of Free Carboxylic Acids with Ammonia in Organic Solvents.

Mike J. J. Litjens, Adrie J. J. Straathof, Jaap A. Jongejan, Joseph J. Heijnen

Journal:

Year:

2000

File:

PDF, 29 KB

2000

6

Optimal re-design of primary metabolism in Escherichia coli using linlog kinetics

Diana Visser, Joachim W. Schmid, Klaus Mauch, Matthias Reuss, Joseph J. Heijnen

Journal:

Metabolic Engineering

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

7

Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum

Roelco J. Kleijn, Feng Liu, Wouter A. van Winden, Walter M. van Gulik, Cor Ras, Joseph J. Heijnen

Journal:

Metabolic Engineering

Year:

2007

Language:

english

File:

PDF, 263 KB

english, 2007

8

Exploration of lipase-catalyzed direct amidation of free carboxylic acids with ammonia in organic solvents

Mike J.J. Litjens, Adrie J.J. Straathof, Jaap A. Jongejan, Joseph J. Heijnen

Journal:

Year:

1999

Language:

english

File:

PDF, 550 KB

english, 1999

9

Filamentous bulking sludge—a critical review

António M.P Martins, Krishna Pagilla, Joseph J Heijnen, Mark C.M van Loosdrecht

Journal:

Year:

2004

Language:

english

File:

PDF, 390 KB

english, 2004

10

Model-based evaluation of temperature and inflow variations on a partial nitrification–ANAMMOX biofilm process

Xiaodi Hao, Joseph J Heijnen, Mark C.M Van Loosdrecht

Journal:

Year:

2002

Language:

english

File:

PDF, 232 KB

english, 2002

11

Effect of feeding pattern and storage on the sludge settleability under aerobic conditions

António M.P. Martins, Joseph J. Heijnen, Mark C.M. van Loosdrecht

Journal:

Year:

2003

Language:

english

File:

PDF, 454 KB

english, 2003

12

Influence of C4-dicarboxylic acid transporters on succinate production

Beauprez, Joeri J., Foulquié-Moreno, Maria R., Maertens, Jo, van Horen, Ellen, Bekers, Katelijne, Baart, Gino J. E., Cunin, Raymond M., Charlier, Daniel, Heijnen, Joseph J., Soetaert, Wim

Journal:

Green Chemistry

Year:

2011

Language:

english

File:

PDF, 562 KB

english, 2011

13

Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model: towards rational scale-down and design optimization

Haringa, Cees, Tang, Wenjun, Wang, Guan, Deshmukh, Amit T., van Winden, Wouter A., Chu, Ju, van Gulik, Walter M., Heijnen, Joseph J., Mudde, Robert F., Noorman, Henk J.

Journal:

Chemical Engineering Science

Year:

2017

Language:

english

File:

PDF, 13.57 MB

english, 2017

14

A new combined differential-discrete cellular automaton approach for biofilm modeling: Application for growth in gel beads

Cristian Picioreanu, Mark C. M. van Loosdrecht, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

1998

Language:

english

File:

PDF, 2.28 MB

english, 1998

15

Minimal aerobic sludge retention time in biological phosphorus removal systems

Damir Brdjanovic, Mark C. M. van Loosdrecht, Christine M. Hooijmans, Guy J. Alaerts, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

1998

Language:

english

File:

PDF, 179 KB

english, 1998

16

A theoretical study on the effect of surface roughness on mass transport and transformation in biofilms

Cristian Picioreanu, Mark C. M. van Loosdrecht, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 1.16 MB

english, 2000

17

Hydrolytic activity in baker's yeast limits the yield of asymmetric 3-oxo ester reduction

Ifoeng Chin-Joe, Pieter M. Nelisse, Adrie J. J. Straathof, Jaap A. Jongejan, Jack T. Pronk, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

18

Effect of diffusive and convective substrate transport on biofilm structure formation: A two-dimensional modeling study

Cristian Picioreanu, Mark C. M. Van Loosdrecht, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 428 KB

english, 2000

19

Strategy for dynamic process modeling based on neural networks in macroscopic balances

Henricus J. L. Van Can, Chris Hellinga, Karel Ch. A. M. Luyben, Joseph J. Heijnen, Hubert A. B. Te Braake

Journal:

Year:

1996

Language:

english

File:

PDF, 1.44 MB

english, 1996

20

Understanding and applying the extrapolation properties of serial gray-box models

Henricus J. L. Van Can, Hubert A. B. Te Braake, Sander Dubbelman, Chris Hellinga, Karel Ch. A. M. Luyben, Joseph J. Heijnen

Journal:

Year:

1998

Language:

english

File:

PDF, 1.86 MB

english, 1998

21

Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous–organic biphasic reactor

Wouter F. Willeman, Pieter Jan Gerrits, Ulf Hanefeld, Johannes Brussee, Adrie J. J. Straathof, Arne van der Gen, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 158 KB

english, 2002

22

Sensitivity analysis of a biofilm model describing a one-stage completely autotrophic nitrogen removal (CANON) process

Xiaodi Hao, Joseph J. Heijnen, Mark C. M. van Loosdrecht

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 209 KB

english, 2002

23

Rapid sampling for analysis of in vivo kinetics using the BioScope: A system for continuous-pulse experiments

Diana Visser, Gertan A. van Zuylen, Jan C. van Dam, Arthur Oudshoorn, Michael R. Eman, Cor Ras, Walter M. van Gulik, Johannes Frank, Gijs W. K. van Dedem, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

24

Correcting mass isotopomer distributions for naturally occurring isotopes

Wouter A. Van Winden, Christoph Wittmann, Elmar Heinzle, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

25

Cumulative bondomers: A new concept in flux analysis from 2D [13C,1H] COSY NMR data

Wouter A. van Winden, Joseph J. Heijnen, Peter J.T. Verheijen

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 273 KB

english, 2002

26

Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation

Wouter A. van Winden, Walter M. van Gulik, Dick Schipper, Peter J.T. Verheijen, Preben Krabben, Jacobus L. Vinke, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2003

Language:

english

File:

PDF, 251 KB

english, 2003

27

A priori analysis of metabolic flux identifiability from 13C-labeling data

Wouter A. van Winden, Joseph J. Heijnen, Peter J. T. Verheijen, Johan Grievink

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001

28

Influence of the ethanol and glucose supply rate on the rate and enantioselectivity of 3-oxo ester reduction by baker's yeast

Ifoeng Chin-Joe, Adrie J. J. Straathof, Jack T. Pronk, Jaap A. Jongejan, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 224 KB

english, 2001

29

Bulking sludge in biological nutrient removal systems

Antönio M. P. Martins, Joseph J. Heijnen, Mark C. M. van Loosdrecht

Journal:

Biotechnology and Bioengineering

Year:

2004

Language:

english

File:

PDF, 434 KB

english, 2004

30

In situ product removal using a crystallization loop in asymmetric reduction of 4-oxoisophorone by Saccharomyces cerevisiae

Evelyn M. Buque-Taboada, Adrie J.J. Straathof, Joseph J. Heijnen, Luuk A.M. van der Wielen

Journal:

Biotechnology and Bioengineering

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

31

Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae

Christoph Wittmann, Michael Hans, Wouter A. van Winden, Cor Ras, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2005

Language:

english

File:

PDF, 210 KB

english, 2005

32

Approximative kinetic formats used in metabolic network modeling

Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2005

Language:

english

File:

PDF, 184 KB

english, 2005

33

Characterization of an experimental miniature bioreactor for cellular perturbation studies

Fredrick O. Aboka, Huiling Yang, Lodewijk P. de Jonge, Rob Kerste, Wouter A. van Winden, Walter M. van Gulik, Rob Hoogendijk, Arthur Oudshoorn, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2006

Language:

english

File:

PDF, 290 KB

english, 2006

34

Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration

Erik E. Krommenhoek, Michiel van Leeuwen, Han Gardeniers, Walter M. van Gulik, Albert van den Berg, Xiaonan Li, Marcel Ottens, Luuk A.M. van der Wielen, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2008

Language:

english

File:

PDF, 315 KB

english, 2008

35

Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions

André B. Canelas, Walter M. van Gulik, Joseph J. Heijnen

Journal:

Biotechnology and Bioengineering

Year:

2008

Language:

english

File:

PDF, 163 KB

english, 2008

36

Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses

Alvaro R. Lara, Hilal Taymaz-Nikerel, Mlawule R. Mashego, Walter M. van Gulik, Joseph J. Heijnen, Octavio T. Ramírez, Wouter A. van Winden

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

37

Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum

Rutger D. Douma, Peter J.T. Verheijen, Wim T.A.M. de Laat, Joseph J. Heijnen, Walter M. van Gulik

Journal:

Biotechnology and Bioengineering

Year:

2010

Language:

english

File:

PDF, 300 KB

english, 2010

38

Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum

Rutger D. Douma, Lodewijk P. de Jonge, Caspar T.H. Jonker, Reza M. Seifar, Joseph J. Heijnen, Walter M. van Gulik

Journal:

Biotechnology and Bioengineering

Year:

2010

Language:

english

File:

PDF, 270 KB

english, 2010

39

Genome-derived minimal metabolic models for Escherichia coli MG1655 with estimated in vivo respiratory ATP stoichiometry

Hilal Taymaz-Nikerel, Amin Espah Borujeni, Peter J.T. Verheijen, Joseph J. Heijnen, Walter M. van Gulik

Journal:

Biotechnology and Bioengineering

Year:

2010

Language:

english

File:

PDF, 373 KB

english, 2010

40

Development of a system for the on-line measurement of carbon dioxide production in microbioreactors: Application to aerobic batch cultivations of Candida utilis

Michiel van Leeuwen, Joseph J. Heijnen, Han Gardeniers, Luuk A. M. van der Wielen, Walter M. van Gulik

Journal:

Biotechnology Progress

Year:

2009

Language:

english

File:

PDF, 188 KB

english, 2009

41

Quantitative determination of glucose transfer between cocurrent laminar water streams in a H-shaped microchannel

Michiel van Leeuwen, Xiaonan Li, Erik E. Krommenhoek, Han Gardeniers, Marcel Ottens, Luuk A. M. van der Wielen, Joseph J. Heijnen, Walter M. van Gulik

Journal:

Biotechnology Progress

Year:

2009

Language:

english

File:

PDF, 438 KB

english, 2009

42

Aerobic batch cultivation in micro bioreactor with integrated electrochemical sensor array

Michiel van Leeuwen, Erik E. Krommenhoek, Joseph J. Heijnen, Han Gardeniers, Luuk A. M. van der Wielen, Walter M. van Gulik

Journal:

Biotechnology Progress

Year:

2010

Language:

english

File:

PDF, 193 KB

english, 2010

43

ChemInform Abstract: Synthesis of Primary Amides by Lipase-Catalyzed Amidation of Carboxylic Acids with Ammonium Salts in an Organic Solvent.

Mike J. J. Litjens, Adrie J. J. Straathof, Jaap A. Jongejan, Joseph J. Heijnen

Journal:

Year:

1999

File:

PDF, 27 KB

1999

44

Technik der anaeroben Abwasserreinigung

Dr.-Ing. Joseph Johannes Heijnen

Journal:

Chemie Ingenieur Technik

Year:

1984

Language:

german

File:

PDF, 796 KB

german, 1984

45

Determination of δ-[L-α-aminoadipyl]-L-cysteinyl-D-valine in cell extracts of Penicillium chrysogenum using ion pair-RP-UPLC-MS/MS

Reza Maleki Seifar, Amit T. Deshmukh, Joseph J. Heijnen, Walter M. van Gulik

Journal:

Journal of Separation Science

Year:

2012

Language:

english

File:

PDF, 191 KB

english, 2012

46

Innovations in Generation and Analysis of 2D [13C,1H] COSY NMR Spectra for Metabolic Flux Analysis Purposes

Wouter van Winden, Dick Schipper, Peter Verheijen, Joseph Heijnen

Journal:

Metabolic Engineering

Year:

2001

Language:

english

File:

PDF, 421 KB

english, 2001

47

The Mathematics of Metabolic Control Analysis Revisited

Diana Visser, Joseph J. Heijnen

Journal:

Metabolic Engineering

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

48

Substrate inhibition and product degradation during the reduction of 4-oxoisophorone by Saccharomyces cerevisiae

Evelyn M. Buque-Taboada, Adrie J.J. Straathof, Joseph J. Heijnen, Luuk A.M. van der Wielen

Journal:

Enzyme and Microbial Technology

Year:

2005

Language:

english

File:

PDF, 487 KB

english, 2005

49

Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats

Mlawule R. Mashego, Mickel L.A. Jansen, Jacobus L. Vinke, Walter M. van Gulik, Joseph J. Heijnen

Journal:

FEMS Yeast Research

Year:

2005

Language:

english

File:

PDF, 225 KB

english, 2005

50

Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards

Liang Wu, Mlawule R. Mashego, Jan C. van Dam, Angela M. Proell, Jacobus L. Vinke, Cor Ras, Wouter A. van Winden, Walter M. van Gulik, Joseph J. Heijnen

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 302 KB

english, 2005